Book Review: "Skinny Bitch" by Rory Freedman and Kim Barnouin (AKA Tweedle Dee and Tweedle DUMB).

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Book Review: "Skinny Bitch" by Rory Freedman and Kim Barnouin (AKA Tweedle Dee and Tweedle DUMB).

So... has anyone actually really read Skinny Bitch? It's horrifying- the way they put their readers down is unparalleled and sums up just how disordered and distorted our society's body image is.

(Note: As Peach Friedman wrote in her memoir "Diary of an Exercise Addict," did you know that only an estimated 2% of women worldwide find themselves beautiful? Two percent!)

If anything, the book is a semi-manual for how to pull the trigger on a full-blown eating disorder. I know this is not me just being sensitive (as I have been in and out of treatment for anorexia nervosa and other eating disorders for over a decade): there's a reason it only receives a meagre 3-star average rating (out of five stars) on Amazon, with 302 out of 1000 reader reviews being a telling one-star rating. Be sure to note, however: Most of the positive reviews just scream disordered thinking and behaviours...

Along those lines, do these self-proclaimed "writers" (an ex-model and former modeling agent, to boot!) really think being vegan is, like, a dieting thing? That's like the PETA billboard's claim that being vegetarian is a great way to lose weight! Uh, no, and if you are becoming vegetarian or vegan to lose weight, you're more than likely just using a euphemism for disordered eating.

And lastly, but certainly not least, the "misogynists" who wrote the book are nutritionists; that is, they are not dietitians. Nutritionists nearly always undergo far less education, experience, certification, internships, and training. How do I know this? My mother-in-law (scroll down to locate "Kathleen") is the chief clinical dietitian and assistant director of nutrition at the hospital here. Trust me, she will correct somebody if they say she's a nutritionist. "No, I went through far too many classes, internships, dietetic certifications, and so on, to be generally labeled as a 'nutritionist'," she often reminds people.

(Please also note this revealing statement: "In many countries only people who have specified educational credentials can call themselves 'dietitians' — the title is legally protected. The term 'nutritionist' is also widely used; however, the term nutritionist is not regulated as dietitian is. People may [as in, "might"- not in the permissive sense] call themselves nutritionists without the educational and professional requirements of registered dietitians.")

Just to drive the point home, I'll conclude by saying this: This book is insanely degrading. The "authors" are not professionals on the topic. They are crude, vulgar, and crass. This book does nothing for our 21st century society, except cause us to take 10 steps backwards, while we desperately need to be moving toward self-realisation and self-acceptance. I do not recommend this drivel to anyone who wants to live life to the fullest by learning intuitive eating, balanced physical activity, and in turn, gaining inner peace. Actually... scratch that. I don't recommend this crap to anyone, period.

(Just for the record: I literally ripped this book up to shreds while in treatment (2007-2008) for an eating disorder. Yes... yes, I did. Why? Because after the real dietitians showed me how to restore and maintain my weight in a healthy manner, based on their knowledge and extensive training, I realised Freedman and Barnouin have gone further than following their own "fad diet" and verbal abuse- they are dangerously promoting: exaggerations, self-deprecation, nutritionally unsound advice, and...let's be honest, themselves.)

Fluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally

Mauro Mileni, Joie Garfunkle, Cyrine Ezzili, Benjamin F. Cravatt, Raymond C. Stevens, and Dale L. Boger

J. Am. Chem. Soc., 2011, 133 (11), pp 4092–4100
DOI: 10.1021/ja110877y
Publication Date (Web): February 28, 2011
Copyright © 2011 American Chemical Society

Two cocrystal X-ray structures of the exceptionally potent α-ketoheterocycle online pharmacy 1 (Ki = 290 pM) bound to a humanized variant of rat fatty acid amide hydrolase (FAAH) are disclosed, representing noncovalently and covalently bound states of the same inhibitor with the enzyme. Key to securing the structure of the noncovalently bound state of the inhibitor was the inclusion of fluoride ion in the crystallization conditions that is proposed to bind the oxyanion hole precluding inhibitor covalent adduct formation with stabilization of the tetrahedral hemiketal. This permitted the opportunity to detect important noncovalent interactions stabilizing the binding of the inhibitor within the FAAH active site independent of the covalent reaction. Remarkably, noncovalently bound 1 in the presence of fluoride appears to capture the active site in the same “in action” state with the three catalytic residues Ser241−Ser217−Lys142 occupying essentially identical positions observed in the covalently bound structure of 1, suggesting that this technique of introducing fluoride may have important applications in structural studies beyond inhibiting substrate or inhibitor oxyanion hole binding. Key insights to emerge from the studies include the observations that noncovalently bound 1 binds in its ketone (not gem diol) form, that the terminal phenyl group in the acyl side chain of the inhibitor serves as the key anchoring interaction overriding the intricate polar interactions in the cytosolic port, and that the role of the central activating heterocycle is dominated by its intrinsic electron-withdrawing properties. These two structures are also briefly compared with five X-ray structures of α-ketoheterocycle-based inhibitors bound to FAAH recently disclosed.

Erectile Disfunction and Neo-Tantric Techniques

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Analysis Supports Use Of Surgery To Treat Medication-Resistant Epilepsy

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Despite authorization exceedingly soon going spare anti-epileptic drugs, 20 percent to 40 percent of all patients beside epilepsy make not counter to medical running. Temporal lobe epilepsy be the precedent undisputed profile of epilepsy and the most prospective to be medically non-responsive, and these patients be at increased activity of early extermination, according to perspective statistics within the article. An alternative form of disposed is temporal lobe resection (procedure where wits tissue in the temporal lobe is gash away). Patients becoming commandeering uncommitted after anterior (toward the front) temporal lobe resection personal reduced death rates comparative to patients continuing to have seizure.

"Studies have report the usefulness of temporal lobe resection since the 1950s, but a minority of patients are one referred to surgery and those one and only after an border line of 20 years of finicky fact. For adolescents and childish adults, this rearrangement may be above all crucial during a critical spell in their psychosocial stirring," the essayist author.

Hyunmi Choi, M.D., M.S., of the Columbia University Mailman School of Public order cialis Professional Pills, New York, and colleagues conduct an analysis using a replication epitome to abrasive estimate the effect of anterior temporal lobe resection vs. seasoned medical management by natural life expectancy and quality-adjusted life expectancy among patients with medication-resistant temporal lobe epilepsy.

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Model forecast of being seizure-free 5 years and 10 years after anterior temporal lobe resection be standardized with grades from published study. The researchers found that anterior temporal lobe resection would put on life expectancy via 5.0 years, with surgery partiality in 100 percent of the simulation, and that resection would increase quality-adjusted life expectancy by 7.5 quality-adjusted life-years, with surgery preferred in 96.5 percent of the simulations.